解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The facultative aerobic bacterium Escherichia coli adjusts its cell cycle to environmental conditions. Because of its lifestyle, the bacterium has to balance the use of oxygen with the potential lethal effects of its poisonous derivatives. Oxidative damages perpetrated by molecules such as hydrogen peroxide and supero...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9110565
更新日期:2018-11-21 00:00:00
abstract::DNA methylation is an essential part of the epigenome chromatin modification network, which also comprises several covalent histone protein post-translational modifications. All these modifications are highly interconnected, because the writers and erasers of one mark, DNA methyltransferases (DNMTs) and ten eleven tra...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9110566
更新日期:2018-11-21 00:00:00
abstract::Leafminer insects of the genus Liriomyza are small flies whose larvae feed on the internal tissue of some of the most important crop plants for the human diet. Several of these pest species are highly uniform from the morphological point of view, meaning molecular data represents the only reliable taxonomic tool usefu...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9110554
更新日期:2018-11-15 00:00:00
abstract::Despite a considerable body of published research on hepatitis B in Bangladesh, researchers continue to lament the lack of reliable information about hepatitis B virus (HBV) infection epidemiology. The present review aims to provide a comprehensive survey of the literature with particular focus on a number of epidemio...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9110541
更新日期:2018-11-08 00:00:00
abstract::Mitogen-activated protein kinase (MAPK) signaling pathway plays key roles in sensing extracellular signals and transmitting them from the cell membrane to the nucleus in response to various environmental stimuli. A MAPKKK protein CgMck1 in Colletotrichum gloeosporioides was characterized. Phenotypic analyses of the ∆C...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9110543
更新日期:2018-11-08 00:00:00
abstract::Transfer RNA (tRNA) is a dynamic molecule used by all forms of life as a key component of the translation apparatus. Each tRNA is highly processed, structured, and modified, to accurately deliver amino acids to the ribosome for protein synthesis. The tRNA molecule is a critical component in synthetic biology methods f...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9110537
更新日期:2018-11-07 00:00:00
abstract::Juvenile open angle glaucoma (JOAG), which is an uncommon form of primary open angle glaucoma, is a clinically and genetically heterogeneous disorder. We report on a family with a recessively inherited form of JOAG. The proband has a superior and an inferior never fiber layer thinning in both the eyes and the nasal vi...
journal_title:Genes
pub_type:
doi:10.3390/genes9110527
更新日期:2018-10-30 00:00:00
abstract::Hepatitis B virus (HBV) is divided into nine genotypes, A to I. Currently, it remains unclear how the individual genotypes contribute to the estimated 250 million chronic HBV infections. We performed a literature search on HBV genotyping data throughout the world. Over 900 publications were assessed and data were extr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9100495
更新日期:2018-10-15 00:00:00
abstract::Asian rice (Oryza sativa) and African rice (Oryza glaberrima) are separately domesticated from their wild ancestors Oryza rufipogon and Oryza barthii, which are very sensitive to daylength. In the process of domestication, some traits that are favorable for the natural survival of wild rice such as seed dormancy and s...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9100489
更新日期:2018-10-10 00:00:00
abstract::Our current knowledge of B chromosome biology has been augmented by an increase in the number and diversity of species observed to carry B chromosomes as well as the use of next-generation sequencing for B chromosome genomic analysis. Within the genus Drosophila, B chromosomes have been observed in a handful of specie...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9100470
更新日期:2018-09-27 00:00:00
abstract::Soil salinity is a serious threat to plant growth and crop productivity. Tall fescue utilization in saline areas is limited by its inferior salt tolerance. Thus, a transcriptome study is a prerequisite for future research aimed at providing deeper insights into the molecular mechanisms of tall fescue salt tolerance as...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9100466
更新日期:2018-09-21 00:00:00
abstract::Candida albicans mutants deficient in homologous recombination (HR) are extremely sensitive to the alkylating agent methyl-methane-sulfonate (MMS). Here, we have investigated the role of HR genes in the protection and repair of C. albicans chromosomes by taking advantage of the heat-labile property (55 °C) of MMS-indu...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090447
更新日期:2018-09-07 00:00:00
abstract::Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9090448
更新日期:2018-09-07 00:00:00
abstract::The reconstruction of ancient metagenomes from archaeological material, and their implication in human health and evolution, is one of the most recent advances in paleomicrobiological studies. However, as for all ancient DNA (aDNA) studies, environmental and laboratory contamination need to be specifically addressed. ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090436
更新日期:2018-08-31 00:00:00
abstract::Network medicine relies on different types of networks: from the molecular level of protein⁻protein interactions to gene regulatory network and correlation studies of gene expression. Among network approaches based on the analysis of the topological properties of protein⁻protein interaction (PPI) networks, we discuss ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9090437
更新日期:2018-08-31 00:00:00
abstract::The relationship between variation of the repetitive component of the genome and domestication in plant species is not fully understood. In previous work, variations in the abundance and proximity to genes of long terminal repeats (LTR)-retrotransposons of sunflower (Helianthus annuus L.) were investigated by Illumina...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090433
更新日期:2018-08-29 00:00:00
abstract::Coat color dilution corresponds to a specific pigmentation phenotype that leads to a dilution of wild type pigments. It affects both eumelanin and pheomelanin containing melanosomes. The mode of inheritance of the dilution phenotype is autosomal recessive. Candidate gene approaches focused on the melanophilin (MLPH) g...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090430
更新日期:2018-08-23 00:00:00
abstract::Perennial agriculture has been proposed as an option to improve the sustainability of cropping systems, by increasing the efficiency of resource use, while also providing ecosystem services. Neo-domestication, the contemporary domestication of plants that have not previously been used in agriculture, can be used to ge...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090422
更新日期:2018-08-21 00:00:00
abstract::Accurate species identification from ancient DNA samples is a difficult task that would shed light on the evolutionary history of pathogenic microorganisms. The field of palaeomicrobiology has undoubtedly benefited from the advent of untargeted metagenomic approaches that use next-generation sequencing methodologies. ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080418
更新日期:2018-08-20 00:00:00
abstract::The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a maj...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080411
更新日期:2018-08-14 00:00:00
abstract::: The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar proteins being encoded in the cell nuclear genome and traffick...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9080412
更新日期:2018-08-14 00:00:00
abstract::Golgi reassembly and stacking protein (GRASP) is required for polysaccharide secretion and virulence in Cryptococcus neoformans. In fungal species, extracellular vesicles (EVs) participate in the export of polysaccharides, proteins and RNA. In the present work, we investigated if EV-mediated RNA export is functionally...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080400
更新日期:2018-08-08 00:00:00
abstract::Functional and folding constraints impose interdependence between interacting sites along the protein chain that are envisaged through protein sequence evolution. Studying the influence of structure in phylogenetic models requires detailed and reliable structural models. Polysaccharide deacetylases (PDAs), members of ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080386
更新日期:2018-07-31 00:00:00
abstract::B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be t...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9080388
更新日期:2018-07-31 00:00:00
abstract::Although genome-wide association studies (GWAS) have identified several hundred loci associated with autoimmune diseases, their mechanistic insights are still poorly understood. The human genome is more complex than single nucleotide polymorphisms (SNPs) that are interrogated by GWAS arrays. Apart from SNPs, it also c...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9080377
更新日期:2018-07-27 00:00:00
abstract::The telomerase RNA in yeasts is large, usually >1000 nt, and contains functional elements that have been extensively studied experimentally in several disparate species. Nevertheless, they are very difficult to detect by homology-based methods and so far have escaped annotation in the majority of the genomes of Saccha...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080372
更新日期:2018-07-26 00:00:00
abstract::Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minirevi...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9070340
更新日期:2018-07-06 00:00:00
abstract::The microRNA (miR)-17 family is widely expressed in mammalian tissues and play important roles in various physiological and pathological processes. Here, the functions of miR-106a-5p, a member of miR-17 family, were explored during myogenic differentiation in C2C12 cell line. First, miR-106a-5p was found to be relativ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9070333
更新日期:2018-07-02 00:00:00
abstract::Although a number of methods have been proposed for identifying differentially expressed pathways (DEPs), few efforts consider the dynamic components of pathway networks, i.e., gene links. We here propose a signaling dynamics detection method for identification of DEPs, DynSig, which detects the molecular signaling ch...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9070323
更新日期:2018-06-27 00:00:00
abstract::microRNA (miRNA) activity and regulation are of increasing interest as new therapeutic targets. Traditional approaches to assess miRNA levels in cells rely on RNA sequencing or quantitative PCR. While useful, these approaches are based on RNA extraction and cannot be applied in real-time to observe miRNA activity with...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060305
更新日期:2018-06-19 00:00:00
abstract::In addition to its wide geographical distribution, osteoglossiform fishes represent one of the most ancient freshwater teleost lineages; making it an important group for systematic and evolutionary studies. These fishes had a Gondwanan origin and their past distribution may have contributed to the diversity present in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060306
更新日期:2018-06-19 00:00:00
abstract::During CRISPR/Cas9 mediated genome editing, site-specific double strand breaks are introduced and repaired either unspecific by non-homologous end joining (NHEJ) or sequence dependent by homology directed repair (HDR). Whereas NHEJ-based generation of gene knock-out is widely performed, the HDR-based knock-in of speci...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060296
更新日期:2018-06-13 00:00:00
abstract::Due to its extraordinary longevity and wide distribution, the ocean quahog Arctica islandica has become an important species model in both aging and environmental change research. Notwithstanding that, most genetic studies on ocean quahogs have been focused on fishery related, phylogeographic and phylogenetic aspects ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060299
更新日期:2018-06-13 00:00:00
abstract::Prader⁻Willi syndrome (PWS) is a complex genetic disorder that, besides cognitive impairments, is characterized by hyperphagia, obesity, hypogonadism, and growth impairment. Proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency, a rare recessive congenital disorder, partially overlaps phenotypically with PW...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9060288
更新日期:2018-06-07 00:00:00
abstract::Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extreme...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9060283
更新日期:2018-06-05 00:00:00
abstract::In this paper, we present a two-phase microfluidic system capable of incubating and quantifying microbead-based agglutination assays. The microfluidic system is based on a simple fabrication solution, which requires only laboratory tubing filled with carrier oil, driven by negative pressure using a syringe pump. We pr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060281
更新日期:2018-06-04 00:00:00
abstract::During speciation-with-gene-flow, a transition from single-locus to multi-locus processes can occur, as strong coupling of multiple loci creates a barrier to gene flow. Testing predictions about such transitions with empirical data requires building upon past theoretical work and the continued development of quantitat...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060274
更新日期:2018-05-24 00:00:00
abstract::During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chro...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9050242
更新日期:2018-05-04 00:00:00
abstract::Yersinia enterocolitica is the causative agent of yersiniosis, a zoonotic disease of growing epidemiological importance with significant consequences for public health. This pathogenic species has been intensively studied for many years. Six biotypes (1A, 1B, 2, 3, 4, 5) and more than 70 serotypes of Y. enterocolitica...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9050235
更新日期:2018-05-03 00:00:00
abstract::Sex chromosomes form once recombination is halted around the sex-determining locus between a homologous pair of chromosomes, resulting in a male-limited Y chromosome. We recently characterized the nascent sex chromosome system in the Trinidadian guppy (Poeciliareticulata). The guppy Y is one of the youngest animal sex...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9050238
更新日期:2018-05-03 00:00:00